Flexeril Uses, Dosage, Side Effects & Warnings

Because cyclobenzaprine is closely related to the tricyclic antidepressants, some of which are known to be excreted in human milk, caution should be exercised when FLEXERIL is administered to a nursing woman. Less frequent dosing should be considered for hepatically impaired or elderly patients (see PRECAUTIONS, Impaired Hepatic Function, and Use in the Elderly). Our Flexeril (cyclobenzaprine) Side Effects Drug Center provides a comprehensive view of available flexeril make you sleepy drug information on the potential side effects when taking this medication. You can call (or for the deaf and the hard of hearing) to talk to a pharmacist about your medication questions. Our pharmacists are available by phone every night from 5pm to 9am – when your community pharmacist may be unavailable. Please call our 24-hour hotline listed above if you need information about treatment for addiction to Flexeril or alcohol for yourself or for a loved one.

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Cyclobenzaprine may be used as part of combination therapy. Ask your pharmacist any questions you have about refilling your prescription. Do not use the extended-release capsules if you have used an MAO inhibitor (MAOI) such as Eldepryl®, Marplan®, Nardil®, or Parnate® within 14 days of each other.

What happens if I miss a dose?

Based on individual patient response, the dose may be increased to 10 mg three times a day. Use of FLEXERIL for periods longer than two or three weeks is not recommended. Cyclobenzaprine is structurally and pharmacologically related to tricyclic antidepressants. Among the most dreaded toxicities linked with cyclical antidepressants, overdoses affect fast-acting sodium channels in the cardiac conduction system. Cyclical antidepressants block the cardiac sodium channel and cause prolongation of cardiac depolarization, which manifests as QRS widening on electrocardiograms.

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The elderly may also be more at risk for CNS adverse events such as hallucinations and confusion, cardiac events resulting in falls or other sequelae, drug-drug and drug-disease interactions. For these reasons, in the elderly, cyclobenzaprine should be used only if clearly needed. In such patients FLEXERIL should be initiated with a 5 mg dose and titrated slowly upward. Clinicians should monitor for signs and symptoms of serotonin syndrome if the patient is taking other serotonergic drugs.

How should I use this medication?

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here. Talk with your doctor about other drug options that may work for you. As with all medications, the costs of cyclobenzaprine can vary.

• Before combining and taking any of them, one must assess the medical risks that come with them to ensure that necessary actions are taken as needed.
• A psychiatrist consult is required for deliberate poisoning of cyclobenzaprine.
• These may be symptoms of a serious condition called serotonin syndrome.
• If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor.

Adverse effects, particularly dizziness and drowsiness, are consistently reported with all skeletal muscle relaxants. The potential adverse effects should be communicated clearly to the patient. Because of limited comparable effectiveness data, choice of agent should be based on side-effect profile, patient preference, abuse potential, and possible drug interactions. Cyclobenzaprine is related structurally and pharmacologically to the tricyclic antidepressants (TCAs). Like other SMRs, cyclobenzaprine produces its effects within the CNS, primarily at the brainstem level.

For neck pain, however, mixed results are obtained (Peloso et al 2005). There are no extensive studies on the use of cyclobenzaprine in the management of painful orofacial musculoskeletal conditions. The results suggest that cyclobenzaprine is superior to both placebo and clonazepam when added to self-care and education for the management of jaw pain upon awakening. In this study cyclobenzaprine (10mg/d) failed to significantly improve sleep in the short term but this may have been due to the relatively low dose employed.

Skeletal muscle relaxants are often prescribed for musculoskeletal conditions including low back pain, neck pain, fibromyalgia, tension headaches, and myofascial pain syndrome. The goals of treatment include managing muscle pain and improving functional status so the patient can return to work or resume previous activities. If cyclobenzaprine is being misused, however, the person may continue to take the medication for much longer and may increase their dose too high, which could lead to dangerous side effects and overdose. Flexeril is an effective pharmacological treatment for muscle spasms and pain, but it can lead to an increased risk of side effects and dependency when mixed with alcohol.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Appropriate studies have not been performed on the relationship of age to the effects of cyclobenzaprine extended-release capsules in the pediatric population.

One study compared FLEXERIL 5 mg and 10 mg t.i.d. to placebo; and a second study compared FLEXERIL 5 mg and 2.5 mg t.i.d. to placebo. Primary endpoints for both trials were determined by patient-generated data and included global impression of change, medication helpfulness, and relief from starting backache. Each endpoint consisted of a score on a 5-point rating scale (from 0 or worst outcome to 4 or best outcome).